Marinos C. Dalakas, M.D.

Education: Dr. Dalakas graduated with honors in 1972 from the National University of Athens Medical School, Athens Greece. He completed his internship in 1974 at Albany Medical School in Albany, New York, and his Neurology residency in 1977 at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School.

Specialized training and Senior Appointments: From 1977-1980, he served as a Fellow in Neuromuscular diseases and from 1981-1986 as a Senior Investigator in Neurovirology and Neuroimmunology, all at the National Institute of Neurological Disorders and Stroke, NIH, Bethesda MD. In 1987, he became the Chief of the Neuromuscular Diseases Section at the National Institute of Neurological Disorders and Stroke, a position he held for more than 20 years, till 2007. Dr. Dalakas has been now appointed Professor of Neurology and Chief of the Neuromuscular Division at Thomas Jefferson University in Philadelphia. In 1997 he was elected Professor and Chairman of the Neurology Department at the University of Athens Medical School in Greece. He is also Professor of Clinical Neurology and Pediatrics at Children's National Medical Center of the George Washington University School of Medicine.

Dr. Dalakas is board certified in Neurology, a Fellow of the American Academy of Neurology, and a Member of the American Neurological Association, the European Neurological Society, the World Muscle Society, the French Neurological Society and the Greek Neurological Association. He is an author or co-author of more than 470 scientific papers or chapters in peer-review Journals. He has edited 11 books and monographs and serves on the editorial board of several journals.

Honors and Awards: He has received several awards including the NIH Director's Award, the U.S. Public Health Service Special Recognition Award, the Duchenne-Erb-Prize by the Deutsche Gesellschaft zur Bekampfung der Musskelkrankheiten e. V, (DGBM), Germany, the Ramsay Medal by the Ramsay Society of London, the Onassis Foundation Visiting Scholarship Award, and the Gaetano Conti Prize for Clinical research. He has been awarded three times, the NIH's "Bench-to-Bedside" Award.

Research and Clinical Interests: His research is focused on exploring the immune, viral and genetic basis of various neuromuscular, demyelinating and neuronal disorders affecting muscle, nerves or brain, and applying new therapeutic interventions via target-oriented control therapeutic clinical trials.

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Select CIDP Publications by Marinos C. Dalakas, M.D.

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• Dalakas M, Houff SA, Engel WK, Madden DL and Sever JL. CSF monoclonal bands in chronic relapsing polyneuropathy. Neurology 30:864-867;1980.
• Dalakas M and Engel WK. Immunoglobulin deposits in chronic relapsing polyneuropathies. Arch Neurol 37:637-640;1980.
• Dalakas MC and Engel WK. Chronic relapsing (dysimmune) polyneuropathy: pathogenesis and treatment. Ann Neurol 9 (suppl):134-145;1981.
• Dalakas MC, Teravinen H, Engel WK. Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies: Incidence and management. Arch Neurol 41:711-714;1984.
• Sanes J, Mauritz KH, Evarts EV, Dalakas MC, Chu A. Motor deficits in patients with large fiber sensory neuropathy. Proc Natl Acad Sci (USA) 81:979- 982;1984.
• Sanes JN, Mauritz KH, Dalakas MC, Evarts EV. Motor control in humans with large-fiber sensory neuropathy. Human Neurobiol 4:185- 199;1985.
• Ilyas AA, Mithen FA, Dalakas MC, Wargo M., ZiWei C, Bielory L, Cook SD. Antibodies to sulfated glycolipids in Guillain-Barre‘ Syndrome. J Neurol Sci 105:108-117;1991.
• Ilyas AA, Mitchen FA, Dalakas MC, Chen ZW, Cook SD. Antibodies to acidic glycolipids in Guillain Barre’ syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Sci 107:1111-1211;1992.
• Illa I, Ortiz N, Gallard E, Juarez C, Grau JM, Dalakas MC. Acute axonal Guillain Barré syndrome with IgG antibodies against motor axons following parenteral injection of gangliosides. Ann Neurol 38:218-224;1995.
• Weiss MD, Luciano CA, Semino-Mora C, Dalakas MC, Quarles R. Molecular mimicry in chronic inflammatory demyelinating polyneuropathy and melanoma. Neurology, 51:1738-1741;1998.
• Dalakas MC. Autoimmune Peripheral Neuropathies. Strategies in Immunotherapy. Advances of Neuroimmunol 5:3-8,1998.
• Dalakas MC. Advances in chronic inflammatory demyelinating polyneuropathy: disease variants and inflammatory response mediators and modifiers. Curr Opinion in Neurology 12:403-409;1999.
• Murata K, Dalakas MC. Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in Chronic Inflammatory Demyelinating Polyneuropathy. Brain 2000;123:1660-1666.
• Dalakas MC. Autoimmune Peripheral Neuropathies. In: Clinical Immunology, Rich RR, Fleisher TA, Shearer WT, Kotzin BL, Schroeder HW (eds). Mosby Year Book Inc., St. Louis, MO 78.1-78.17, 2001.
• Hughes RA, Bensa S, Willison HJ, Van der Bergh P, Comi G, Illa I, Nobile-Orazio E, van Doorn P, Dalakas MC, Bojar M, Swan A and the inflammatory neuropathy course and treatment (INCAT) group. Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy. Ann Neurol 2000;50:195-201.
• Dalakas MC. Blockade of blocking antibodies in Guillain-Barré Syndromes: “Unblocking” the mystery of action of IVIg. Ann Neurol 2002;51:667-669.
• Dalakas MC. Mechanism of action of IVIg and therapeutic considerations in the treatment of acute and chronic demyelinating neuropathies. Neurology 2002;59:S13-21.
• Gold R, Dalakas MC, Toyka KV. Immunotherapy in autoimmune neuromuscular disorders. Lancet Neurology. 2003;2:22-32.
• Dalakas MC. Viral related muscle disease. In: Engel AG (ed) Myology (3rd Edition). McGraw Hill. New York. 2004;1389-1417.
• McCrone P, Chisholm D, Knapp M, Hughes R, Comi G, Dalakas MC, Illa I, Kilindireas C, Nobile-Orazio E, Swan A, Van den Bergh P, Willison HJ and the INCAT Group: Cost-utility Analysis of Intravenous Immunoglobulin and Prednisolone for Chronic Inflammatory Demyelinating Polyradiculoneuropathies (CIDP). Eur J Neurol. 2003;10:687-694
• Berger AR, Bradley WG, Brannagen TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menker DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI, Neuropathy Association, Medical Advisory Committee. Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst 2003;8:282 – 284.
• Renaund S, Hays AP, Brannagan TH, Sander HH, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N. Gene expression profiling in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). J Neuroimmunol. 2005;159:203-14.
• Latov N, Gorson KC, Brannagan TH, Freeman RL, Apostolski S, Berger AR, Bradley WG, Briani C, Bril V, Busis NA, Cros DP, Dalakas MC et al. Diagnosis and treatment of chronic immune-mediated neuropathies. J Clin Neuromusc Dis 2006;7:141-157.

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