Investigations to Be Considered (EFNS/PNS)
Carol L. Koski, M.D. and Richard A. Lewis, M.D., Principal Authors
Information adapted from Joint Task Force of the EFNS and the PNS, 2005
To Identify CIDP
- Nerve conduction studies
- Cerebrospinal fluid cells and protein
- MRI spinal roots, brachial plexus, and lumbosacral plexus
- Nerve biopsy
To Detect Concomitant Diseases
- Serum and urine paraproteins detection by immunofixation (repeating this should be considered in patients who are or become unresponsive to treatment)
- Oral glucose tolerance test
- Complete blood count
- Renal function
- Liver function
- HIV antibody
- Hepatitis B and C serology
- Borrelia burgdorferi serology
- C reactive protein
- Antinuclear factor
- Extractable nuclear antigen antibodies
- Thyroid function
- Angiotensin-converting enzyme
- Chest radiograph
- Skeletal survey (repeating this should be considered in patients who are or become unresponsive to treatment)
To Detect Hereditary Neuropathy
- Examination of parents and siblings
- PMP22 gene duplication or deletion (especially if slowing of conduction is uniform and no evidence of partial motor conduction block or abnormal temporal dispersion)
- Gene mutation known to cause CMT1 or heredity neuropathy with liability to pressure palsies
CMT1, Charcot-Marie-Tooth disease type 1
