Pathogenesis (Immunopathogenesis)
Marinos C. Dalakas, M.D., Principal Author
CIDP is a multifocal disorder that primarily affects spinal nerve roots, spinal nerves, major plexus, proximal nerve trunks and peripheral nerves. (Kieseier, 2002) CIDP lesions extend throughout the peripheral nervous system (PNS). In some cases, these lesions also extend to the intramuscular nerves, the sympathetic trunks, and the terminal autonomic nerves. (Dyck, 1993) Both cellular and humoral immune factors are involved in CIDP. (Rezania, 2004)
